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Effects to the Gastrointestinal Tract and various Clean Muscle Codeine will cause a reduction in motility connected with a rise in sleek muscle tone in the antrum with the stomach and duodenum. Digestion of foodstuff in the small intestine is delayed and propulsive contractions are decreased.Unresponsive Cough The dosage of Promethazine with Codein

Daily life-threatening respiratory despair and Loss of life have occurred in youngsters who acquired codeine. Codeine is topic to variability in metabolism based mostly on CYP2D6 genotype (explained below), which may result in an elevated exposure towards the active metabolite morphine. Dependent on post-advertising and marketing reviews, little on